What is hypertensive nephropathy?

Hypertensive nephropathy is caused by essential hypertension in benign small arterial nephrotic (also known as hypertensive renal arteriosclerosis) and malignant small arterial nephrosclerosis with associated clinical manifestations of disease, hypertension and renal failure.

Many years of history of hypertension, renal tubular damage earlier than the glomerular, nocturia increased urinary enrichment function, urine changes lighter, mild proteinuria, may have microscopic hematuria and tube type, often Other target organ complications of hypertension.

Hypertensive nephropathy found: that the general increase in blood pressure (/ Kpa / mmHg above); some eyelids and / or lower extremity edema, cardiac enlargement, etc .; most arteriosclerotic retinopathy, when the eye has a stripe-like flame-like bleeding And cotton-like soft exudation, support malignant renal arteriosclerosis, diagnosis associated with hypertensive encephalopathy may have the corresponding signs of the nervous system.


In clinical practice, according to the patient's condition and laboratory tests, hypertension is usually divided into the following period:

Phase I - microalbuminuria: characterized by abnormal albumin excretion rate in urine. Normal renal function, normal urine protein negative;

Phase Ⅱ - clinical proteinuria: urine protein was positive, 24 h urine protein quantitative "0.5g is characterized by normal renal function.


Phase Ⅲ - renal insufficiency: characterized by decreased Ccr and elevated SCr. Non-dialysis and dialysis (uremia).

Non-dialysis: Ccr at 40 ~ 10ml / min, 133μmol / L "Scr" 707μmol / L.

Dialysis period (uremia period): Ccr "10ml / min. Scr "707 μmol / L.

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